Dr. Lei Ye

EDUCATION

YEAR DEGREE FIELD OF STUDY INSTITUTION

1996 MD Clinical Medicine Shanghai Medical University, China

2005 PhD Biomedical Science National University of Singapore

POSITION

lye@uab.edu

YEAR POSITION

2010–2014 Assistant Professor, University of Minnesota

2014-2022 Principal Investigator, National Heart Centre Singapore

2019-2022 Associate Professor, Duke-NUS Medical School, National University of Singapore

2022-present Associate Professor, Dept. Biomedical Engineering, the University of Alabama at Birmingham

RESEARCH

- Roles of the extracellular matrix in cardiovascular injury

- Cell transplantation for Myocardial Repair.

BIO

Dr. Ye received his Ph.D. from the National University of Singapore in 2005. He completed postdoctoral training in multipotent adult progenitor cells at the University of Minnesota and human pluripotent stem cell biology and reprogramming and in vitro differentiation of human pluripotent stem cells into cardiovascular lineages at Stanford University. Then, he completed his residency in the Department of Cardiac Surgery at the ZhongShan Hospital in Shanghai before serving as a Research Assistant in both the Department of Surgery at Queen Mary Hospital at the University of Hong Kong and the National University Medical Institutes at the National University of Singapore.

In 2010, Dr. Ye began in his first faculty position as assistant professor in the University of Minnesota’s Department of Medicine, where he worked with Dr. Zhang in many cardiovascular research projects. In 2014, he returned to the National University of Singapore. In 2022, he rejoined Zhang lab at UAB.

He has been a member of the American Heart Association, the European Society of Cardiology, and the European Council for Cardiovascular Research. He has served as an American Heart Association Scientific Session Abstract reviewer and an Open Fund Young Individual Research Grant Panel Member. Ye has served on the National Medical Research Council in Singapore and the French National Research Agency. He has been a member of eight editorial board services.

SELECTED PUBLICATION

1. Zhang Z, Dalan R, Hu ZY, Wang JW, Chew NWS, Poh KK, Tan RS, Soong TW, Dai YL*, Ye L*, Chen XY*. Reactive Oxygen Species Scavenging Nanomedicine for The Treatment of Ischemic Heart Disease. Advanced Materials. 25 April 2022. doi:10.1002/adma.202202169.

2. Tao ZH, Loo SJ, Su LP, Tan SH, Tee GZ, Gan SU, Zhang JY, Chen X*, Ye L*. Angiopoietin-1 enhanced myocyte mitosis, engraftment, and the reparability of hiPSC-CMs for treatment of myocardial infarction. Cardiovascular Research. 1 June 2021. 117(6): 1578–1591.

3. Tan S, Loo S, Gao Y, Tao Z, Su L, Wang C, Zhang SL, Mu Y, Cui Y, Desiree A, Wang W, Janise L, Lim K, Bu J, Tan R, Lee TH, Zhang J, Ye L*. Thymosin β4 increases cardiac cell proliferation, cell engraftment, and the reparative potency of human induced-pluripotent stem cell–derived cardiomyocytes in a porcine model of acute myocardial infarction. Theranostics 2021; 11(16): 7879-7895.

4. Ye L*, D’Agostino G, Loo SJ, Wang CX, Su LP, Tan SH, Tee GZ, Pua CJ, Pena EM, Cheng RB, Chen WC, Abdurrachim D, Lalic J, Tan RS, Lee TH, Zhang JY, Cook SA*. Early regenerative capacity in the porcine heart. Circulation 2018 Dec 11;138(24): 2798-2808.

5. Ye L, Chang YH, Xiong Q, Zhang PY, Zhang LY, Somasundaram P, Lepley M, Swingen C, Su LP, Wendel JS, Guo J, Jang A, Rosenbush D, Greder L, Dutton JR, Zhang JH, Kamp TJ, Kaufman DS, Ge Y, Zhang JY. Cardiac repair in a porcine model of acute myocardial infarction with human induced pluripotent stem cell-derived cardiovascular cells. Cell Stem Cell 2014 Nov; 15(6): 750-761